Covid treatments: What works, what doesn't, what might – Daily Monitor

Health workers attend to a Covid-19 patient in the intensive care unit at Mulago Hospital in Kampala recently. Several variants of the viral disease have been confirmed by WHO following its outbreak in 2019. PHOTO/ PROMISE TWINAMUKYE
Overshadowed by the global push for vaccines, the search for treatments for Covid-19 has made steady — if slower — progress.
Here is a look at what works, what might work, and what definitely doesn’t. 
Proven therapies 
The World Health Organization (WHO) has approved three types of Covid-19 treatment.
The first is a class of steroids called corticosteroids, recommended in September 2020 by the UN’s health authority, which said it should only be used by seriously ill patients.
Inexpensive and widely available, the steroid fights the inflammation that commonly accompanies severe cases, reducing the need to be placed on a ventilator and the likelihood of death.
The WHO has also endorsed two known arthritis drugs — tocilizumab and sarilumab — which have been shown to suppress a dangerous overreaction of the immune system to the SARS-CoV-2 virus that causes Covid.
Both drugs, approved in July, likewise reduce the risk of death and the need for ventilators.
And last week the WHO recommended Regeneron, the expensive synthetic antibody cocktail given to former US president Donald Trump during his brush with the virus. 
But it said it should only be used in patients with specific health profiles, for example with non-severe Covid who are still at high risk of hospitalisation.  
Critically ill patients who cannot mount an adequate immune response can also take the antibody combo, the WHO said.
Therapies being tested 
Several labs are working on antiviral drugs that can be taken orally as pills. 
One of the most advanced is molnupiravir, an experimental therapy developed by Ridgeback Biotherapeutics and Merck that is meant to stop the virus from replicating.
Currently in phase 3 trials, the drug is being tested on Covid patients and also as a preventative measure for contact cases. Results are expected by the end of the year.
Atea Pharmaceuticals and Roche laboratories are evaluating a similar treatment.
Vaccine maker Pfizer is also working on a medication that combines two molecules, including one that is already used to combat HIV.
The market for treatments that are “effective and easy-to-administer against early forms of Covid is potentially huge”, said infectious disease specialist Karine Lacombe. 
So far, antiviral medications have not been very effective against Covid.
In May, the US Food and Drug Administration gave sotrovimab — an new monoclonal antibody therapy developed by GSK — emergency use approval for the treatment of mild-to-moderate Covid-19.
The European commission later classified it as one of the five most promising treatments for the disease. 
AstraZeneca released preliminary results of its antibody cocktail at the end of August, saying it could prevent Covid in fragile patients.
And French company Xenothera is working on a different kind of synthetic treatment called “polyclonal antibodies”. Its therapy — based on pig antibodies adapted to the human immune system — is in the final stages of clinical trials. 
What doesn’t work 
Hydroxychloroquine, remdesivir, ivermectin and the HIV drug lopinavir-ritonavir (Kaletra), have all proved ineffective against Covid-19, according to multiple studies and trials.
Despite this, demand for these drugs as Covid treatments remains high, fuelled in large part by dodgy or fraudulent claims on social media. 
Researchers had hoped to ‘reposition’ these drugs — try them on Covid patients even though they were created to fight other conditions.
“Repositioning a drug is what you do in an emergency at the very beginning of a pandemic,” said Lacombe.
But the fact that no therapies were able to be repurposed — besides the arthritis anti-inflammatory medication — shows the limit of that kind of approach, she said.
The detectives subjected the complainant to medical examination. The doctor’s report indicated that the complainant had been harmed
His re-arrest came hours after President Museveni slammed courts of law for granting bail to murder suspects and vowed to fight it politically…

source

198 thoughts on “Covid treatments: What works, what doesn't, what might – Daily Monitor”

  1. Heya i am for the primary time here. I found this board and I
    in finding It really useful & it helped me out much.
    I hope to present one thing back and aid others like you helped me.

  2. you’re in point of fact a good webmaster.
    The website loading pace is amazing. It kind of feels that you’re
    doing any distinctive trick. Furthermore,
    The contents are masterpiece. you’ve done a excellent process
    in this topic!

  3. I do agree with all of the ideas you have introduced on your
    post. They’re really convincing and can certainly work.

    Nonetheless, the posts are very short for newbies. Could you please extend them
    a bit from subsequent time? Thanks for the post.

  4. Its like you read my mind! You appear to know a lot about this, like you wrote
    the book in it or something. I think that you could do with a few
    pics to drive the message home a little bit, but other than that, this is magnificent blog.
    An excellent read. I’ll definitely be back.

  5. Today, I went to the beachfront with my children. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She placed the shell to her ear and screamed.
    There was a hermit crab inside and it pinched her ear. She never wants to go back!

    LoL I know this is totally off topic but I had to tell someone!

  6. Hey I know this is off topic but I was wondering if you knew of any
    widgets I could add to my blog that automatically tweet my
    newest twitter updates. I’ve been looking for a plug-in like this
    for quite some time and was hoping maybe you would have some experience with something like this.
    Please let me know if you run into anything. I truly enjoy reading your blog and
    I look forward to your new updates.

  7. Pingback: 2premium

  8. Hello there! I know this is kinda off topic nevertheless I’d figured I’d ask.
    Would you be interested in exchanging links or maybe guest writing a blog post or vice-versa?
    My site discusses a lot of the same topics as yours and I believe we could greatly benefit from each other.
    If you might be interested feel free to shoot me an e-mail.

    I look forward to hearing from you! Excellent blog
    by the way!

Leave a Comment

Your email address will not be published.